The Herrmann AFM Group
Elucidating the mechanisms of action of bioactive natural products by AFM


Original articles

  • N. Knetzger, S. Lehmann, A. Hensel, E. Liebau, F. Herrmann. The anthelmintic quassinoids Ailanthone and Bruceine B induce infertility in the model organism Caenorhabditis elegans by an apoptotic mechanism occuring in gonadal and spermathecal tissues. (under preparation)

  • F. C. Herrmann. Easy ultrastructural insight into the internal morphology of biological specimens by Atomic Force Microscopy. Sci. Rep., 2021, 11:10214, DOI: 10.1038/s41598-021-89633-2.
  • S. C. Gangadharappa, I. Maisuls, I. P. Salto, S. Niemann, V. Bachtin, F. C. Herrmann, C. A. Strassert. An interplay between intermolecular interactions and self-assembly of nanoclay in luminescent Pt(II) complex-nanoclay hibrids. J. Phys. Chem. C, 2021, DOI:10.1021/acs.jpcc.0c09835
  • S. Lehmann, F. Herrmann, K. Kleemann, V. Spiegler, E. Liebau, A. Hensel. Extract and the quassinoid ailanthone from Ailanthus altissima inhibit nematode reproduction by damaging germ cells and rachis in the model organism Caenorhabditis elegans. Fitoterapia, 2020, 146:104651, DOI: 10.1016/j.fitote.2020.104651.
  • N. C. Stein, D. Mulac, J. Fabian, F. C. Herrmann, K. Langer. Nanoparticle albumin-bound mTHPC for photodynamic therapy: Preparation and comprehensive characterisation of a promising drug delivery system. Int. J. Pharm., 2020, 582:119347, DOI: 10.1016/j.ijpharm.2020.119347.
  • I. Lengers, F. Herrmann, M. Le Borgne, J. Jose. Improved Surface Display of Human Hyal1 and Identification of Testosterone Propionate and Chicoric Acid as New Inhibitors. Pharmaceuticals (Basel), 2020, 13(4), pii: E54 DOI: 10.3390/ph13040054.
  • F. C. Herrmann, V. Spiegler. Caenorhabditis elegans revisited by Atomic Force Microscopy - Ultra-structural changes of the cuticle, but not the intestine after treatment with Combretum mucronatum extract. J. Struc. Biol., 2019, 208(2), 174 - 181. 
  • N. M. Kimani, S. Backhaus, J. C. Matasyoh, M. Kaiser, F. C. Herrmann, T. J. Schmidt, K. Langer. Preparation of Sesquiterpene Lactone-Loaded PLA Nanoparticles and Evaluation of Their Antitrypanosomal activity. Molecules, 2019, 24(11), pii: E2110.
  • K. Partikel, R. Korte, N. C. Stein, D. Mulac, F. C. Herrmann, H. U. Humpf, K. Langer. Effect of nanoparticle size and PEGylation on the protein corona of PLGA nanoparticles. Eur. J. Pharm. Biopharm., 2019, 141, 70 - 80.
  • J. Anderski, L. Mahlert, J. Sun, W. Birnbaum, D. Mulac, S. Schreiber, F. Herrmann, D. Kuckling, K. Langer. Light-responsive nanoparticles based on new polycarbonate polymers as innovative drug delivery systems for photosensitizers in PDT. Int. J. Pharm., 2019, 557, 182 - 191.
  • F. C. Herrmann, N. Sivakumar, J. Jose, M. P. Costi, C. Pozzi, T. J. Schmidt. In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I. Molecules, 2017, 22(12), pii: E21166. 
  • F. C. Herrmann, M. Lenz, J. Jose, M. Kaiser, R. Brun, T. J. Schmidt. In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase. Molecules, 2015, 20(9), 16154 - 69.
  • J. Schmuch, S. Beckert, S. Brandt, G. Löhr, F. Herrmann, T. J. Schmidt, T. Beikler, A. Hensel. Extract from Rumex acetosa L. for prophylaxis of periodontitis: inhibition of bacterial in vitro adhesion and of gingipains of Porphyromonas gingivalis by epicatechin-3-O-(4ß->8)-epicatechin-3-O-gallate (procyanidin-B2-Di-gallate). PLoS One, 2015, 10(3), e0120130.
  • A. Derksen, A. Hensel, W. Hafezi, F. Herrmann, T. J. Schmidt, C. Ehrhardt, S. Ludwig, J. Kühn. 3-O-galloylated procyanidins from Rumex acetosa L. inhibit the attachment of influenza A virus. PLoS One, 2014, 9(10), e110089.

Conference contributions

  • F. Herrmann. From a biological activity to a potential target - How to use ultrastructural Atomic Force Microscopy as a tool to elucidate mechanisms of action. WWU.USP 4th Scientific Workshop & Winter School "Cells under Fire", Münster, Februar 2020. (Winter School Lecture)
  • M. K. Amstalden, J. C. Ferreira, F. Herrmann, A. L. C. Dairini, R. D. Cummings, S. R. Stowell, M. D. Baruffi. LPS-targeting galectins-3 and .4 on blood group b positive E. coli O86: new aspects on its microbial action and association with antibiotics. 12th International Congress of Pharmaceutical Sciences (CIFARP), Ribeirao Preto, Brasilien, November 2019. (Posterpräsentation)
  • T. Saenger, M. Schulte, F. C. Herrmann, M. Pattberg, S. Vordenbäumen, E. Beck, M. Schneider, J. Jose. Phosphorylation of breast-milk alphaS1-casein induced conformational changes and abolished TLR4-agonisticity as well as formation of fibril structure. 5th International Electronic Conference on Medicinal Chemistry, Oktober 2019.
  • F. C. Herrmann. Assessing the internal morphology of Caenorhabditis elegans by AFM - A facile, ultra-microtomy based approach to identify treatment associated ultrastructural alterations. 9th AFM BioMed Conference, Münster, Germany, September 2019. (Kurzvortrag)
  • D. Dornbusch, F. C. Herrmann. Das parasitäre Zytoskelett als Target innovativer antileishmanialer Therapien - Ultrastrukturelle Untersuchungen an subpellicularen Microtubuli von Leishmania tarentolae. 5th Young Researcher Meeting, Münster, 2019. (Kurzvortrag)
  • I. Lengers, F. Herrmann, S. Haidar, J. Jose. Human Hyal-1 - from in silico pharmacophore modeling to in vitro inhibitor screening. 3rd International Electronic Conference on Medicinal Chemistry, November 2017. (Posterpräsentation)
  • F. C. Herrmann, N. Sivakumar, T. J. Schmidt. In silico identification and in vitro evaluation of new flavonoid inhibitors of pteridine reductase I from Leishmania major (LmPTR1). 65th International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research, Basel, Schweiz, September 2017. (Kurzvortrag)
  • F. C. Herrmann, T. J. Schmidt. 2,3-Dehydrosilybin: A new potent inhibitor of Glyceraldeyhde-3-phosphate-dehydrogenase from Trypanosoma brucei identified by in silico screening and an enzyme inhibition assay. 63rd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research, Budapest, Ungarn, August 2015; Planta Medica, 2015, 16(81). (Kurzvortrag)
  • F. C. Herrmann, M. Lenz, T. J. Schmidt. Identifizierung neuer TbGAPDH-Inhibitoren natürlichen Ursprungs mittels eines in silico Screenings. 4th Young Researcher Meeting, Münster, März 2015. (Kurzvortrag)
  • F. C. Herrmann, T. J. Schmidt. Discovery of new TbGAPDH inhibitors of natural origin by an in-silico screening approach. COST Action CM1307/CaPF, Calvi, Korsika, November 2014. (Kurzvortrag)
  • F. C. Herrmann, M. Lenz, T. J. Schmidt. Identification of natural compounds inhibiting Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase by in-silico screening and a spectrophotometric enzyme inhibition assay. 62nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research, Guimaraes, Portugal, September 2014, Plant Medica, 2014, 80(16). (Postepräsentation und Kurzvortrag sowie 1. Preis für beste Präsentation des Young Researcher Meetings 2014)
  • F. C. Herrmann, T. J. Schmidt. In silico screening of natural product databases reveals new potential leads against neglected tropical diseases. 61th International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research, Münster, Planta Medica, 2013, 79(13). (Posterpräsentation)

Supervised master theses

  • Nicola Knetzger, "Rasterkraftmikroskopische Analyse der Wirkung verschiedener Quassinoide gegen Caenorhabditis elegans", 2020
  • Daniel Dornbusch, "Entwicklung einer rasterkraftmikroskopischen Methode zur Visualisierung morphologischer Veränderungen an Leishmanien nach Behandlung mit Tubulin-modifizierenden Wirkstoffen", 2019
  • Katharina Possart, "Rationale Suche nach Naturstoffen mit antitrypanosomaler Aktivität", 2019
  • Nirina Sivakumar, "Naturstoffe mit Hemmwirkung auf die Pteridinreduktase 1 von Leishmania major und Trypanosoma brucei", 2016
  • Alexandra Heithorst, "Mechanistische Untersuchungen zur Hemmung trypanosomaler Enzyme durch ausgewählte Naturstoffe", 2016